Journal: Cancer Cell International
Article Title: Liquid biopsy-derived extracellular vesicle protein biomarkers for diagnosis and prognostic assessment of lung squamous cell carcinoma
doi: 10.1186/s12935-025-03792-0
Figure Lengend Snippet: Plasma EV protein biomarkers for the diagnosis of LUSC. ( A ) Proteins with the highest predictive values in classifying LUSC and BLD with XGBoost. ( B ) ROC curve and confusion matrix in the training set. ( C ) ROC curve and confusion matrix in the test set. ( D ) ROC curve and confusion matrix in the entire cohort. SEN (Sensitivity) and SPE (Specificity) refer to diagnostic performance metrics for distinguishing LUSC from BLD samples. ( E ) Levels of TUBB3 in total plasma from patients with LUSC and BLD. A total of 74 samples (38 BLD and 36 LUSC) were tested. ( F ) Levels of RPS7 in total plasma from patients with LUSC and BLD. A total of 149 samples (44 BLD and 105 LUSC) were tested
Article Snippet: Following the manufacturer’s instructions, commercial assay kits for RPS7 (MyBioSource, USA, Catalog Number: MBS7204349) and TUBB3 (CUSABIO, China, Catalog Number: CSB-E14121h) were used to determine the expression levels of these proteins in preoperative plasma samples.
Techniques: Clinical Proteomics, Biomarker Discovery, Diagnostic Assay